Progress in Physics ›› 2023, Vol. 43 ›› Issue (2): 41-55.doi: 10.13725/j.cnki.pip.2023.02.002

Special Issue: 2023年, 第43卷

Previous Articles    

Cell Tissue Simulations Based on Active Network Models

LI Zhu-qin, LEI Qun-li, MA Yu-qiang   

  1. National Laboratory of Solid State Microstructures and Department of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China
  • Online:2023-04-20 Published:2023-04-23
  • Supported by:
    National Natural Science Foundation of China (No. 11974175, No. 12174184, No. 12247102, No. 12275127).


In the last decade, motivated by advances in cell biology, theoretical studies of the cell tissue as active matter have emerged as a new area in soft matter physics. This article reviews recent theoretical progresses based on the active network (AN) model of cell tissue. In the mesoscopic scale, the non-equilibrium dynamics of cell tissue is mainly driven by the self-propulsion of cells and non-propulsion activities, like active contractility or cellular tension/volume oscillation. AN models of self-propelled cells can reproduce complex dynamics of cell tissue in vivio, such as activity/adhesion driven solid-liquid transition, flocking and active turbulence. The AN model incorporating cellular tension fluctuation can also simulate the cell volume oscillation waves in embryo of Drosophila, and predict the fluctuation-driven solid-liquid transition of cell tissue. The structural phase transition and density fluctuation of cell tissue were also studied by using AN models, which deepens our understanding of this unique non-equilibrium soft matter system.

Key words: cell tissue, active network models, dynamic and transition

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